Teaching MCC CUREs

11 Mar

Written By Guest User

Information here will be used at the 2024 MCC Fellows Cohort and Professional Development Workshop in San Diego
MCC PyMOL Homework (Prof Dev):
1) Go through the videos and instructions in this handout.
PreVirtual Homework (Cohort):
1) Watch the Homework Video
2) Get an account for mdhcures.org>MCC members only pages https://www.mdhcures.org/mcc-members-only
3) Watch theLoop mutation video
4) Watch video about phosphomimic mutations(Min 1-8 and 40-51)
5) Complete Google form form to let us know which project and which isoform/region you wanthoose your project
** Please complete all of this including the Google form no later than June 23!
Virtual Workshop Agenda (Cohort) See the Slack Cohort Channel for links
Day 1
1-145   Welcome, Plan for Virtual, 2024 Cohort Meet each other
145 -215 Elements of a CURE (Amy)
215-245 2024 Cohort breakout by project choice (Amy,Joe)
break
3-3:30 Members of previous cohort join (Ivy, Elena, Varuni talk about their CURE experience)
3:30- 4 Questions to speakers, or about projects
Day 2
1-130   Hypothesis development and your CURE (Kevin Callahan)
130-2   Developing a syllabus (Joe)
2 – 2:45 Pitfalls to avoid (all, members of previous cohorts join)
Break
3 -3:45   Breakout rooms to talk about syllabus and project
345-4   Wrap up, next steps – details about in person workshop (Joe)
In Person Meeting (Cohort and Prof Dev) Click for full agenda
In Person Homework - Cohort AND Prof Dev. Review the two videos (alphaFold3 / SeamDock) in prep for working dinner on modeling
1 ml Enzyme Assay
Purification PPT
More Prof Dev and Cohort Links to come
Research Elements of an MDH CURE
OUR Community Key Component Expanded Description
CURES to teach Biological Thinking (Bell BAMBED 2020)
Example Hypothesis Development for MDH-CS Interaction CURE
Full Semester Template
Modular Example Template
Community College
N. Hennepin CC -Biology Focus
SW CC -Chemistry Focus
Primarily Undergraduate Institution
Upper Div Biochem Lab 1
Upper Div Biochem Lab 2
Upper Div Biochem Lab 3
Comprehensive and R1 University
Upper Div Biochem Lab 1
Upper Div Biochem Lab 2
Upper Div Biochem Lab 3
First Year Chem & Biol
First Year Chem - Full Semester Drug Design
First Year Chem -Modular MDH & Cancer
Hybrid and Virtual
Virtual CURE
Have a syllabi or link to your MDH CURE you want to share? Email your hub leader (Ellis Bell, Lisa Gentile Amy Springer) or Joseph Provost.
Hypothesis Development Rubrics
- Find and present relevant primary literature and supporting evidence for hypothesis development
- Understand the roles that non-covalent interactions play in enzyme structure and function
- Develop and present a testable hypothesis with appropriate experiments
OUR Pedagogical Key Components, Goals and Assessment
Publications (papers and reviews)
CUREs in biochemistry-where we are and where we should go
Development and Use of CUREs in Biochemistry
Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE
External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs
Length of course-based undergraduate research experiences (CURE) impacts student learning and attitudinal outcomes: A study of the Malate dehydrogenase CUREs Community (MCC)
Increasing access for biochemistry research in undergraduate education: The malate dehydrogenase CURE community
Developing Course Undergraduate Research Experiences (CUREs) in Chemistry
Using inquiry and research-based learning in a year-long biochemistry laboratory: Part I-guided inquiry-purification and characterization of a fusion protein: Histidine tag, malate dehydrogenase, and green fluorescent protein
Using inquiry and research-based learning in a year-long biochemistry laboratory : Part II-research-based laboratory-a semester-long research approach using malate dehydrogenase as a research model
It is all about the students…
Project: Malate Dehydrogenase CURE Community
Abstracts
The Evolution of the Malate Dehydrogenase CUREs Community
Community college course-based undergraduate research experiences in chemistry, biochemistry and biology classes resulted in significant student gains for persons excluded due to ethnicity or race
Creating and Using the Malate Dehydrogenase CURE Community to Explore Critical Aspects of Sustainable Protein Centric CUREs
Protein Engineering of a Spectroscopic Probe into Malate Dehydrogenase (MDH)
MDH CURE Community Faculty Fellows: A new mentoring program supporting Biochemistry CUREs
Authentic research in the teaching laboratory at a large university: comparative studies of malate dehydrogenase isoforms in trypanosomes
MDH protein interactions and phosphorylation: Engaging students with a novel scientific theme using CUREs
OTHER
AddGene Course-Based Undergraduate Research Experiences (CUREs)
Send J Provost links to your publications, abstracts or other materials to include on this page.
Start Up Page
Suggested Equipment List
Teamwork and Colalboration
Key Elements of MDH CUREs
Tips and Hints to Teaching a CURE
Student Handout - Hypothesis Development MDH-CS Interaction
MDH Phosphorylation - Gen Chem Materials (go to members only)
MCC Discount at BioRad (Save up to 60% off Bio-Rad list prices! MCC is a Bio-Rad Explorer education program preferred pricing partner and members can receive additional discounts on equipment, reagents, and consumables for their MCC courses – Go to the Members Only Page to find links to save!)

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